PATIENTS AND METHODS: The prospective multicenter noninterventional study NABUCCO collected data on the routine treatment of patients with MBC receiving nab-P in 128 sites across Germany. I'm Ashish Kamat from Houston, at MD Anderson Cancer Center. Ashish Kamat: Because looking at this, it looks like INSTILADRIN, which again, full disclosure, was developed at my place, is almost twice as better as the immunotherapies, but I just want to caution our audience that that's-. Лекарства из Израиля | Доставка по России и СНГ | ManorPharm Thanks for the opportunity for sharing the key ASCO updates. Shilpa Gupta: Yeah, that's a great question, Ashish.

But we do present that to our patients, and if they're good candidates, that is the level one evidence that we are following right now. And neither was the interim overall survival, in the intention-to-treat population. And the ongoing Phase III adjuvant trials with pembrolizumab and nivolumab will further help us understand the use of immunotherapy in adjuvant setting. And this shows comparable results. And after completion of chemotherapy, if patients had stable disease, fascial, or complete responses, they were randomized to avelumab and best supportive care, versus best supportive care alone. Ashish Kamat: Yeah. Unfortunately, this was a negative trial, as we can see here. Advanced and metastatic breast cancer; Albumin-bound paclitaxel; Disease progression; Observational study; Outpatients. Most patients received all three cycles, and immune-related adverse events did occur in around 54% of patients. Ashish Kamat: Six-week dosing. As we have also enacted with nivolumab, all original studies were every two weeks, but we are using the flat dose every four weeks. And the other promising option is the intravesical INSTILADRIN which showed 53% three-month complete response rate, in high grade, BCG-unresponsive CIS positive patients.

And the primary analysis populations were all intention-to-treat patients, as well as PD-L1 positive population.

There's a lot going on in the bladder cancer field, and I'm delighted to share the key updates. Patients reported no apparent treatment-related impact on global quality of life. Clipboard, Search History, and several other advanced features are temporarily unavailable. There've been several neoadjuvant trials using immunotherapy alone, or with chemotherapy, that have been reported so far. If you follow [inaudible] evidence, you obviously have to stick with the data that was presented in Tom Powles' study. eCollection 2015. In fact, it was presented last year at ASCO. I'm sorry. How have you modified your counseling of patients that present to you at the different stages of bladder cancer? Ashish Kamat: And since many of the studies were actually done before the six-week schedule was established. Shilpa Gupta: I think it would be great to see some neoadjuvant immunotherapy trials readout, or at least in trend data available so we can start using it. And we saw that TGF beta was associated with resistance to immunotherapy like human mutational burden was felt to be correlating with responses. A new version of the defunct Nabucco gas pipeline project is being prepared, this time based on the transport of Russian gas, … Privacy Policy And then, in moving back to the other studies that you mentioned. Moving on to adjuvant immunotherapy approaches in muscle-invasive bladder cancer. Correct. The key thing here that I would highlight is that patients with visceral metastasis seem to benefit if they had PD-L1 positive, and otherwise the benefit was not as pronounced as other categories. This was a study of preoperative ipilimumab and nivolumab in stage III urothelial cancer. Please enable it to take advantage of the complete set of features! Perhaps that's what failed to get a response. Shilpa Gupta: No, I think, you're right. This was the SWOG S1605 study presented by Dr. Peter Black. Advanced Prostate Cancer Consensus Conference (APCCC), American Society of Clinical Oncology (ASCO), European Society for Medical Oncology (ESMO), International Bladder Cancer Network (IBCN), Society of Nuclear Medicine and Molecular Imaging (SNMMI), Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction (SUFU), World Congress of Endourology and SWL (WCE), COVID-19 and Genitourinary Cancers Videos, Large Urology Group Practice Association (LUGPA), Precision Medicine: PSMA Targeted Therapies in Progressive Metastatic Prostate Cancer Videos, Nocturia & Lower Urinary Tract Conditions, ASCO 2020: Biomarker Analysis and Updated Clinical Follow-Up Of Preoperative Ipilimumab Plus Nivolumab in Stage III Urothelial Cancer (NABUCCO), ASCO 2020: JAVELIN Bladder 100 Phase III Results: Maintenance Avelumab + Best Supportive Case vs BSC Alone After Platinum-Based First-Line Chemotherapy in Advanced Urothelial Carcinoma, JAVELIN Bladder 100: Results of First-line Maintenance Therapy Plus Best Supportive Care Demonstrates Significant Prolonged OS in Advanced Urothelial Cancer - Cora Sternberg, IMvigor010 Primary Analysis from a Phase III Randomized Study of Adjuvant Atezolizumab versus Observation in High-Risk Muscle-Invasive Urothelial Carcinoma - Thomas Powles & Matthew Galsky. The primary objective was time to progression. (Eithan Elkin) (Eithan Elkin) This was maintenance avelumab, and best supportive care versus best supportive care alone, after platinum-based first-line chemotherapy in advanced urothelial carcinoma. NIH Secondary objectives were overall response rate, overall survival, safety, and quality of life. The arm with carcinoma in situ, plus-minus Ta/T1 data was presented. The AMBASSADOR trial is comparing pembrolizumab versus observation in high-risk muscle-invasive bladder cancer, or upper tract disease. Nabucco, Verdi’s third opera, is based on the Old Testament Bible story about the Babylonian king Nabucodonosor (ca. The prospective multicenter noninterventional study NABUCCO collected data on the routine treatment of patients with MBC receiving nab-P in 128 sites across Germany.

Patients received ipilimumab loading dose, followed by Ipi Nivo, and one dose of nivolumab.

What are you most excited about? Starting with the neoadjuvant immunotherapy approaches in muscle-invasive bladder cancer. With overall survival, not reached in avelumab and best supportive care arm, and 17 months in the best supportive care arm. We know that based on the KEYNOTE-057, pembrolizumab is approved in this setting, and the treatment complete response rate with that is 41%. And it was more pronounced in the PD-L1 positive arm, being 5.7 months with avelumab, versus 2.1 months in best supportive care arm. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error.  |  In the rare circumstance where they cannot get carboplatin, we treat them with single-agent immunotherapy, or if they have high PD-L1 expression in their tumors, and they are cisplatin-ineligible, then they also meet the criteria. So with that, Dr. Gupta, take it away. And in the PD-L1 positive population, the results were even more pronounced. The addiction later extended to other drugs such as oxycodone (Percocet). | I appreciate the opportunity. Contact us. Turkmenistan has since made efforts to break out of Russia's hold on its exports.

The safety was reasonably in line with what we see, however, there was a treatment-related death on this study. Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) as second-line chemotherapy in HER2-negative, taxane-pretreated metastatic breast cancer patients: prospective evaluation of activity, safety, and quality of life. I have a couple of questions for you. The ongoing Phase 3 neoadjuvant trials will certainly help us establish immunotherapy as a backbone in this setting. Real-world data of nab-P in MBC, however, are still limited. 2017 Nov;24(6):783-789. doi: 10.1007/s12282-017-0779-7. Shilpa Gupta: Thank you, Ashish. Dr. It is building a major gas pipeline to China and is considering taking part in the Nabucco pipeline - an EU-backed project designed to provide an alternative to Russian gas supplies … The disease-free survival was similar in both the groups, it was not significantly different. A quick question about the dosing schedule.

Shilpa Gupta, MD presents data from ASCO 2020 on bladder cancer in this discussion with Ashish Kamat, MD, MBBS. The key study that was presented at ASCO this year was the IMvigor010. The results were similar in patients aged < 65 versus ≥ 65 years as well as in patients who received nab-P on a weekly or a triweekly schedule. We also participated in the pembrolizumab Hoosier study led by Dr. Matt Galsky, which also utilized the switch maintenance approach. USA.gov. So it did not meet the primary endpoint. I think that would be what I'd be most excited about. In a 2005 interview, Gruber spoke publicly about her addictions to painkillers and prescription drugs, where she admitted that her problems with drugs began at age 11. They also looked at several biomarkers, like tumor mutational burden, intratumoral TDH, and TGF data associated genes. Or do you think that they're interchangeable enough that practices that have more familiarity with one of the other agents could use that as maintenance therapy? This was the primary analysis from the Phase III randomized trial of adjuvant atezolizumab versus observation in high risk muscle-invasive urothelial carcinoma. Now, this has been great, a great discussion and lots more I could ask you, but in the interest of time, let me ask you one last question. This website uses cookies to ensure you get the best experience on our website. Get the latest public health information from CDC: https://www.coronavirus.gov. 2007 Jul;7(7):919-43. doi: 10.1586/14737140.7.7.919. Epub 2014 Feb 12. Correct? The subgroup analysis favored avelumab across the board. The results of the NABUCCO study confirm the clinical trial outcomes and the favorable safety profile of nab-P in patients with metastatic breast cancer in a real-world setting. Patients received ipilimumab loading dose, followed by Ipi Nivo, and one dose of nivolumab. Terms and Conditions Another trial is looking at nivolumab in these patients. Nab-paclitaxel for breast cancer: a new formulation with an improved safety profile and greater efficacy. Your financial support helps build the future of our network of newsrooms across Europe. The only difference from the IMvigor trial is that this does allow positive margins, IMvigor010 did not.

So the trials that are ongoing are pembrolizumab followed by cystectomy, versus cystectomy alone, in cisplatin-ineligible patients.

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