Pregnant and breastfeeding women and young kids must avoid using this herb. These cookies do not store any personal information. The feverfew herb has a long history of use in traditional and folk medicine, especially among Greek and early European herbalists. Parthenolide has also inhibited Mycobacterium tuberculosis and Mycobacterium avium at a minimum inhibitory concentration of 16 and 64 mcg/mL.51. Bleeding may occur. This website uses cookies to improve your experience while you navigate through the website. Medically reviewed by Drugs.com. The bitter taste is often offset by the addition of sweeteners. As far as the proper dosage is concerned, it has to be decided by a qualified herbalist. Earlier, feverfew leaves (both in fresh and dried forms) were used for this purpose. Feverfew is used to relieve headaches, particularly vascular headaches such as migraines. Additionally, an ethanolic extract of feverfew inhibited the growth of 2 human breast cancer lines, human glioblastoma cell lines, and 1 human cervical cancer cell line. It has also been indicated that these active ingredients in feverfew may curb inflammation of the blood vessels in the head. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. However, there are certain studies that do not support these claims. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. Bleeding may occur. Feverfew action does not appear to be limited to a single mechanism. Migraine frequency declined from 4.8 attacks to 2.9 attacks (−1.9 ± 0.2) in patients treated with feverfew compared with 3.5 attacks (−1.3 ± 0.2) with placebo at weeks 5 through 12. If you choose to grow feverfew indoors from seed, be sure to use quality soil. Nausea and vomiting were reduced in patients taking feverfew, but the statistical analysis has been questioned.72 These results were confirmed in a placebo-controlled study in 72 patients suffering from migraine.73 On the basis of their research, investigators predicted that feverfew may be useful not only for classical migraine and cluster headaches, but also for premenstrual, menstrual, and other headaches.70, Studies at the City of London Migraine Clinic revealed that the experimental observations may not be clinically relevant to migraine patients taking feverfew. This result is likely due to a higher percentage of runts in the feverfew-treated mice.87, Agents with antiplatelet properties: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of agents with antiplatelet properties. The product significantly improved erythema, overall irritation, and tactile roughness as noted by the participants and investigators (P < 0.05).85, Feverfew may have a potential role as an antiepileptic agent. It is also claimed to be an effective remedy for headaches, especially those caused by migraines. In general, there are 5 different types of sesquiterpene lactones, which may be classified by chemical ring structures. Though optimal doses of feverfew have not been established, an adult dosage of parentholide 0.2 to 0.6 mg/day is recommended for the prevention of migraine. In fact, it is an important herb used in the European folk medicine. The number of migraine attacks per 28 days was less in the feverfew group.76, A Cochrane review of evidence from double-blind, randomized, controlled trials was inconclusive in establishing the efficacy of feverfew for preventing migraine headaches. Consider therapy modification.95, 96, 97, 98, Adverse reactions in patients administered feverfew 50 mg/day (roughly equivalent to 2 leaves) during 6 months of treatment were mild and did not result in discontinuation, with 4 of 8 patients experiencing no adverse effects. Costa Ricans use a decoction of the herb to aid digestion, as a cardiotonic, an emmenagogue, and as an enema for worms. You should talk with your health care provider for complete information about the risks and benefits of using this product. Results from the meta-analysis reported insufficient evidence to conclude whether feverfew was superior to placebo in reducing the frequency and severity of migraine attacks, incidence and severity of nausea and vomiting, and global assessment of efficacy in patients with migraine headaches. The PD-feverfew inhibited the activity of 5-lipoxygenase, phosphodiesterase-3, and phosphodiesterase-4. Secondary end points were total and average duration, intensity of migraine attacks, and number of days with accompanying migraine symptoms. Consider therapy modification.95, Nonsteroidal anti-inflammatory agents: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of nonsteroidal anti-inflammatory agents. Would you like to write for us? As stated above, feverfew (Tanacetum parthenium/Chrysanthemum parthenium/Pyrethrum parthenium) has been used a medicinal herb for a very long time. What Is the Difference Between a D.O. In case of capsules and tablets, a dosage of 100 to 300 milligrams per day is suggested. Bleeding may occur. When tested if feverfew extracts could interfere with cytokine production in THP-1 cells, it was discovered that cells pretreated with feverfew extracts had a reduction in lipopolysaccharide-mediated TNF-alpha release in a dose-dependent fashion.40, Feverfew parthenolide-free extract is suggested to have antioxidant and anti-inflammatory activity. The safety of long-term use has not been established. Upon patch testing, both women tested positive to various allergens including a sesquiterpene lactone mix and the moisturizer, leading to the conclusion that feverfew moisturizer was responsible for their dermatitis.50, 69, 100, 101 Other adverse effects have included nausea, vomiting, abdominal pain, diarrhea, indigestion, and flatulence.7, Because no studies of long-term toxicity have been performed on the plant, the safety of feverfew use has not been established. Parthenolide also enhanced the production of nitric oxide and superoxide anion in all of the ALL cells.55 Thus, parthenolide may be a future treatment option for patients with leukemia to selectively destroy the leukemic stem cells while sparing normal stem cells. For an overview of all of our herbal remedies, go to the main, To learn more about treating medical conditions at home, visit our main, One of the best things you can do for your health and well being is to make sure you are getting enough of the vital nutrients your body needs. In Mexico, it’s used as an antispasmodic and a tonic to regulate menstruation. Feverfew can be grown either indoors or outdoors from seed. Feverfew plants, also known as altamisa or febrifuge plant, is a short traditional medicinal herb that is commonly used to prevent migraine headaches. Feverfew has been studied in combination with other products for the treatment of migraine headaches.77, 78, 79 Poor methodology (low number of participants and open-label design) and the use of feverfew with other natural products makes attribution of the study findings to feverfew itself, problematic. Last updated on Dec 20, 2018. Pregnant women should not use the plant because the leaves possess emmenagogue activity (ejection of the placenta and fetal membranes) and may induce abortion. It has also been used for inflammation, arthritis, menstrual discomforts, fever, and other aches and pains. Inhibition was irreversible and the effect was not due to cytotoxicity. Though there is no conclusive evidence to prove the effectiveness of feverfew for migraine headaches, the herb is widely used and is found to be effective for many. Two case reports describe women who developed dermatitis soon after using a facial moisturizer containing feverfew. In Mexico, it is used as an antispasmotic and as a tonic to regulate menstruation. We comply with the HONcode standard for trustworthy health information -. Patients withdrawn from feverfew may experience ill effects often known as "postfeverfew" syndrome. These cytokines are dependent on the transcription factor NF-kappa-B for secretion. It also inhibited the release of pro-inflammatory mediators, such as nitric oxide, prostaglandin E2, and tissue necrosis factor (TNF)-alpha from macrophages and TNF-alpha IL-2, IFN-gamma, and IL-4 from human peripheral blood mononuclear cells. It was also discovered that parthenolide was stable when the environmental pH was between 5 to 7 but unstable at a pH of 3 or less. The mechanism of action associated with parthenolide does not involve inhibition of 5-HT2 receptors directly, but rather occurs at the level of 5-HT stored in vesicles of the intramural neurons of fundal tissue.44, Rat aortic vascular smooth muscle cells were isolated and treated with varying concentrations of parthenolide (10, 20, and 30 mcmol/L). Even those who are allergic to feverfew and those who develop allergic reactions after using it must avoid using the herb. In Venezuela, it’s used for treating earaches. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. Research has suggested that malignant stem cells are the source for several types of cancers in humans. The leaf extracts inhibited contractions induced by potassium depolarization much less. Results suggest that feverfew's inhibition of prostaglandin synthesis differs in mechanism from that of salicylates.23, 24, 34, 35, 36, Phospholipase A2 inhibition in platelets has been documented. This is because it might raise your body’s propensity to bleed. Its yellow tubular florets, each with 10 to 20 white rays, bloom from July to October and are about 2 cm in diameter. The plant that is native to the Eurasian regions is also grown for ornamental purposes, as it produces small daisy-like flowers. One hundred forty-seven patients suffering from migraine with or without aura according to International Headache Society criteria were treated. Of these, 245 were up-regulated genes and 155 were down-regulated with feverfew extracts. We've created informative articles that you can come back to again and again when you have questions or want to learn more! Of all the constituents of feverfew tests, parthenolide demonstrated the greatest inhibitory effect.58 Another in vitro study demonstrated that parthenolide was effective at inhibiting the proliferation of human lung carcinoma, human medulloblastoma, human colon adenocarcinoma, and human umbilical vein endothelial cells.59 Results from another study suggest that parthenolide given in combination with hyperthermia (ie, heat) may increase thermosensitization of human lung adenocarcinoma cells via induction of apoptosis or cell cycle arrest through inhibition of nuclear factor (NK)-kappa-B activation.60 One study documents how parthenolide may influence and enhance the effectiveness of paclitaxel.5, 32, 39, 42, 61, 62, 63, 64, 65, Parthenolide is being investigated in early clinical studies for a therapeutic role in cancer.105, A proposed mechanism of action involves parthenolide inhibition of the NF-kappa-B pathway by blocking I-kappa-B kinase (IKK-beta), an activator of NF-kappa-B.6, 30 The IKK-beta complex plays an important role in pro-inflammatory cytokine-mediated signaling.

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